{PDOC00099}
{PS00106; GALACTOKINASE}
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* Galactokinase signature *
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Galactokinase  (EC 2.7.1.6) [1]  catalyzes  the  first reaction  of  galactose
metabolism,  the  conversion  of  galactose  to  galactose 1-phosphate.  There
are three well conserved regions in the sequence of eukaryotic and prokaryotic
galactokinase.  As a signature pattern we have selected the  best conserved of
these regions, which is located in the N-terminal section of galactokinase.

In yeast the GAL3 protein [2] is required for rapid induction of the galactose
system. The exact function of GAL3 is not known, but it may be involved in the
production of a true inducer or coinducer  molecule.   The sequence of GAL3 is
closely related to that of galactokinases.

-Consensus pattern: G-R-x-N-[LIV]-I-G-[DE]-H-x-D-Y
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Note: See also the section describing the pattern  for  the GHMP kinases ATP-
 binding domain <PDOC00545>.

-Last update: July 1999 / Pattern and text revised.

[ 1] Debouck C., Riccio A., Schumperli D., McKenney K., Jeffers J.,
     Hughes C., Rosenberg M., Heusterspreute M., Brunel F., Davison J.
     "Structure of the galactokinase gene of Escherichia coli, the last (?)
     gene of the gal operon."
     Nucleic Acids Res. 13:1841-1853(1985).
     PubMed=3158881
[ 2] Bajwa W., Torchia T.E., Hopper J.E.
     "Yeast regulatory gene GAL3: carbon regulation; UASGal elements in
     common with GAL1, GAL2, GAL7, GAL10, GAL80, and MEL1; encoded protein
     strikingly similar to yeast and Escherichia coli galactokinases."
     Mol. Cell. Biol. 8:3439-3447(1988).
     PubMed=3062381

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