{PDOC00111}
{PS00121; COLIPASE_1}
{PS51342; COLIPASE_2}
{BEGIN}
*****************************************
* Colipase family signature and profile *
*****************************************

Colipase [1,2,3] is  a  protein   that  functions as a cofactor for pancreatic
lipase, with  which  it  forms  a stoichiometric complex. It also binds to the
bile-salt covered triacylglycerol interface thus allowing the enzyme to anchor
itself to the water-lipid interface.

As shown  in  the  following  schematic  representation,  colipase  is a small
protein of approximately 100 amino-acid residues with five conserved disulfide
bonds.

                           +--------+
                        +--|--+     |    +----------+
                        |  |  |     |    |   *****  |
                xxxxxxxxCxxCxCCxxxxxCxxxxCxxxxxCxCxxCxxxxxxxxCxxxx
                             |                 | |           |
                             +-----------------+ +-----------+

'C': conserved cysteine involved in a disulfide bond.
'*': position of the pattern.

As  a  signature pattern for this family, we chose a region which includes two
of  the  cysteines  involved  in  disulfide  bonds,  as well as three tyrosine
residues  which  seem  to  be  involved  in  the  interfacial binding. We also
developed a profile that covers the whole colipase.

-Consensus pattern: Y-x(2)-Y-Y-x-C-x-C
                    [The 2 C's are involved in disulfide bonds]
                    [The 3 Y's are involved in interfacial binding]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: December 2007 / Text revised; profile added.

[ 1] Erlanson-Albertsson C.
     "Pancreatic colipase. Structural and physiological aspects."
     Biochim. Biophys. Acta 1125:1-7(1992).
     PubMed=1567900
[ 2] Chapus C., Rovery M., Sarda L., Verger R.
     "Minireview on pancreatic lipase and colipase."
     Biochimie 70:1223-1234(1988).
     PubMed=3147715
[ 3] van Tilbeurgh H., Sarda L., Verger R., Cambillau C.
     "Structure of the pancreatic lipase-procolipase complex."
     Nature 359:159-162(1992).
     PubMed=1522902; DOI=10.1038/359159a0

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{END}