{PDOC00203} {PS00231; F_ACTIN_CAPPING_BETA} {BEGIN} ************************************************** * F-actin capping protein beta subunit signature * ************************************************** The F-actin capping protein binds in a calcium-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike gelsolin and severin this protein does not sever actin filaments. The F-actin capping protein is a heterodimer composed of two unrelated subunits: alpha and beta. The beta subunit is a protein of about 280 amino acid residues whose sequence is well conserved in eukaryotic species [1]. As a signature pattern we chose a conserved hexapeptide in the N-terminal section of the beta subunit. -Consensus pattern: C-[DE]-[YF]-N-R-D -Sequences known to belong to this class detected by the pattern: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: December 2004 / Pattern and text revised. [ 1] Amatruda J.F., Cannon J.F., Tatchell K., Hug C., Cooper J.A. "Disruption of the actin cytoskeleton in yeast capping protein mutants." Nature 344:352-354(1990). PubMed=2179733 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}