{PDOC00218} {PS00245; PHYTOCHROME_1} {PS50046; PHYTOCHROME_2} {BEGIN} ******************************************* * Phytochrome chromophore attachment site * ******************************************* Phytochrome [1,2,3] is a plant protein that acts as a regulatory photoreceptor and which mediates red-light effects on a wide variety of physiological and molecular responses. Phytochrome can undergo a reversible photochemical conversion between a biologically inactive red light-absorbing form and the active far-red light-absorbing form. Phytochrome is a dimer of identical 124 Kd subunits, each of which contains a covalently attached linear tetrapyrrole chromophore. The chromophore is attached to a cysteine which is located in a highly conserved region that can be used as a signature pattern. Synechocystis strain PCC 6803 hypothetical protein slr0473 contains a domain similar to that of plants phytochrome and seems to also bind a chromophore. -Consensus pattern: [RGS]-[GSA]-[PV]-H-x-C-H-x(2)-Y [C is the chromophore attachment site] -Sequences known to belong to this class detected by the pattern: ALL, except for slr0473. -Other sequence(s) detected in Swiss-Prot: NONE. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Expert(s) to contact by email: Partis M.D.; mickp@hotmail.com -Last update: November 1997 / Pattern and text revised; profile. [ 1] Silverthorne J., Tobin E.M. BioEssays 7:18-23(1987). [ 2] Quail P.H. "Phytochrome: a light-activated molecular switch that regulates plant gene expression." Annu. Rev. Genet. 25:389-409(1991). PubMed=1812812; DOI=10.1146/annurev.ge.25.120191.002133 [ 3] Quail P.H. "The phytochromes: a biochemical mechanism of signaling in sight?" BioEssays 19:571-579(1997). PubMed=9230690 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}