{PDOC00220}
{PS00247; HBGF_FGF}
{BEGIN}
*****************************
* HBGF/FGF family signature *
*****************************

Heparin-binding growth factors I and II (HBGF) [1,2] (also known as acidic and
basic fibroblast growth factors (FGF) are  structurally related mitogens which
stimulate growth or differentiation of a wide  variety  of cells of mesodermal
or neuroectodermal origin.  These  two  proteins  belong to a family of growth
factors and oncogenes which is currently known [3,4] to include:

 - FGF-3  (int-2),  induced  by  the  integration of mouse mammary tumor virus
   (MMTV).
 - FGF-4  (hst-1;  KS3),  a transforming protein independently isolated from a
   human stomach tumor (hst-1) and from Kaposi's sarcoma (KS3).
 - FGF-5, an oncogene expressed in neonatal brain.
 - FGF-6  (hst-2),  a  transforming protein that exhibits strong mitogenic and
   angiogenic properties.
 - FGF-7  or  keratinocyte growth factor (KGF), a paracrine effector of normal
   epithelial cell proliferation.
 - FGF-8 or androgen-induced growth factor (AIGF).
 - FGF-9 or glia-activating factor (GAF), a heparin-binding growth factor that
   may have   a   role   in  glial  cell  growth  and  differentiation  during
   development.
 - FGF-11  (FHF-3),  FGF-12  (FHF-1),  FGF-13  (FHF-2) and FGF-14 (FHF-4) [5],
   which seem to be involved in nervous system development and function.
 - FGF-15,  which  may  play an important role in regulating cell division and
   patterning within  specific regions of the embryonic brain, spinal cord and
   sensory organs.
 - FGF-16.
 - FGF-17.
 - FGF-18, which stimulates hepatic and intestinal proliferation.
 - FGF-19,
 - A  FGF  homolog  of  unknown  function  from Autographa californica nuclear
   polyhedrosis virus [6].

From  the sequences  of these  related proteins, we  have  derived a signature
pattern which includes one of the two conserved cysteine residues.

-Consensus pattern: G-x-[LIM]-x-[STAGP]-x(6,7)-[DENA]-C-x-[FLM]-x-[EQ]-x(6)-Y
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2004 / Pattern and text revised.

[ 1] Burgess W.H., Maciag T.
     "The heparin-binding (fibroblast) growth factor family of proteins."
     Annu. Rev. Biochem. 58:575-606(1989).
     PubMed=2549857; DOI=10.1146/annurev.bi.58.070189.003043
[ 2] Thomas K.A.
     "Transforming potential of fibroblast growth factor genes."
     Trends Biochem. Sci. 13:327-328(1988).
     PubMed=3072709
[ 3] Benharroch D., Birnbaum D.
     "Biology of the fibroblast growth factor gene family."
     Isr. J. Med. Sci. 26:212-219(1990).
     PubMed=1693362
[ 4] Miyamoto M., Naruo K.-I., Seko C., Matsumoto S., Kondo T., Kurokawa T.
     "Molecular cloning of a novel cytokine cDNA encoding the ninth member
     of the fibroblast growth factor family, which has a unique secretion
     property."
     Mol. Cell. Biol. 13:4251-4259(1993).
     PubMed=8321227
[ 5] Smallwood P.M., Munoz-Sanjuan I., Tong P., Macke J.P., Hendry S.H.,
     Gilbert D.J., Copeland N.G., Jenkins N.A., Nathans J.
     "Fibroblast growth factor (FGF) homologous factors: new members of the
     FGF family implicated in nervous system development."
     Proc. Natl. Acad. Sci. U.S.A. 93:9850-9857(1996).
     PubMed=8790420
[ 6] Ayres M.D., Howard S.C., Kuzio J., Lopez-Ferber M., Possee R.D.
     "The complete DNA sequence of Autographa californica nuclear
     polyhedrosis virus."
     Virology 202:586-605(1994).
     PubMed=8030224

--------------------------------------------------------------------------------
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html
--------------------------------------------------------------------------------

{END}