{PDOC00246}
{PS00273; ENTEROTOXIN_H_STABLE}
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* Heat-stable enterotoxins signature *
**************************************

Prokaryotic heat-stable  enterotoxins [1] are  responsible for acute diarrhea.
The active toxin is  a short  peptide of around twenty residues which contains
six cysteines involved  in  three  disulfide  bonds, as shown in the following
schematic representation:

                                +-------+
                             +--|----+  |
                             |  |    |  |
                          xxCCxxCCxxxCxxCxx
                            |    |
                            +----+

'C': conserved cysteine involved in a disulfide bond.

We have  taken  the pattern of cysteines, along with three conserved residues,
as a signature pattern for this group of proteins.

-Consensus pattern: C-C-x(2)-C-C-x-P-A-C-x-G-C
                    [The 6 C's are involved in disulfide bonds]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: May 2004 / Text revised.

[ 1] Shimonishi Y., Hidaka Y., Koizumi M., Hane M., Aimoto S., Takeda T.,
     Miwatani T., Takeda Y.
     "Mode of disulfide bond formation of a heat-stable enterotoxin (STh)
     produced by a human strain of enterotoxigenic Escherichia coli."
     FEBS Lett. 215:165-170(1987).
     PubMed=3552731;

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