{PDOC00247}
{PS00274; AEROLYSIN}
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* Aerolysin type toxins signature *
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Aerolysin [1]  is a cytolytic  toxin  exported  by the Gram-negative Aeromonas
bacteria.    The mature toxin binds to eukaryotic cells and aggregates to form
holes  (approximately 3 nm in  diameter)  leading  to the  destruction  of the
membrane permeability barrier  and osmotic lysis.   Staphylococcus aureus also
exports a cytotoxin, alpha-toxin [2], whose biological activity  is similar to
that of aerolysin.  The sequences of  both toxins are not similar except for a
stretch of ten residues rather well conserved.

-Consensus pattern: [KT]-x(2)-N-W-x(2)-T-[DN]-T
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Note: Pseudomonas aeruginosa cytotoxin [3] has been said to contain a  region
 whose sequence is similar to that of the conserved domain of areolysin/alpha-
 toxin, but the similarity is very weak and this toxin is not picked up by the
 above pattern.

-Last update: November 1997 / Pattern and text revised.

[ 1] Howard S.P., Garland W.J., Green M.J., Buckley J.T.
     "Nucleotide sequence of the gene for the hole-forming toxin aerolysin
     of Aeromonas hydrophila."
     J. Bacteriol. 169:2869-2871(1987).
     PubMed=3584074
[ 2] Gray G.S., Kehoe M.
     "Primary sequence of the alpha-toxin gene from Staphylococcus aureus
     wood 46."
     Infect. Immun. 46:615-618(1984).
     PubMed=6500704
[ 3] Hayashi T., Kamio Y., Hishinuma F., Usami Y., Titani K., Terawaki Y.
     "Pseudomonas aeruginosa cytotoxin: the nucleotide sequence of the gene
     and the mechanism of activation of the protoxin."
     Mol. Microbiol. 3:861-868(1989).
     PubMed=2507866

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