{PDOC00249}
{PS00276; CHANNEL_COLICIN}
{BEGIN}
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* Channel forming colicins signature *
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Colicins   are plasmid-encoded  polypeptide    toxins  produced by and  active
against Escherichia coli and  closely related bacteria.    The channel-forming
colicins are transmembrane proteins that depolarize the  cytoplasmic membrane,
leading to dissipation  of  cellular energy [1,2].  Colicins A, B, E1, Ia, Ib,
and N belong to that group. The N-terminal part of these colicins  is involved
in their uptake; the central part is important for  binding to outer  membrane
receptors and the C-terminal part is the channel-forming region.

As a signature for  this type  of  colicins, we  have selected one of the most
conserved region of the channel-forming domain.

-Consensus pattern: T-x(2)-W-x-P-[LIVMFY](3)-x(2)-E
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: November 1990 / Text revised.

[ 1] Pattus F., Massotte D., Wilmsen H.U., Lakey J., Tsernoglou D.,
     Tucker A., Parker M.W.
     "Colicins: prokaryotic killer-pores."
     Experientia 46:180-192(1990).
     PubMed=1689257
[ 2] Cramer W.A., Cohen F.S., Merrill A.R., Song H.Y.
     "Structure and dynamics of the colicin E1 channel."
     Mol. Microbiol. 4:519-526(1990).
     PubMed=1693745

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