{PDOC00258}
{PS00286; SQUASH_INHIBITOR}
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*********************************************************
* Squash family of serine protease inhibitors signature *
*********************************************************

The squash family of serine  protease  inhibitor  [1]  is  one of the numerous
families of serine   proteinase inhibitors.   The proteins   belonging to this
family  are found in  the  seeds of  cucurbitaceae  plants  (cucumber, squash,
bitter gourd, etc.).    The basic  structure of  such  a type of inhibitor  is
shown in the following schematic representation:

                          +----------------+
                          |                |
                          *****************|**
                        xxCx#xxxxCxxxxxCxxxCxCxxxxxCx
                                 |     |     |     |
                                 |     +-----|-----+
                                 +-----------+

                        <--------30 residues-------->

'C': conserved cysteine involved in a disulfide bond.
'#': active site residue.
'*': position of the pattern.

The pattern  we have used  to detect  this  family of proteins spans the major
part  of  the  sequence  and  includes five  of  the six cysteines involved in
disulfide bonds.

-Consensus pattern: C-P-x(5)-C-x(2)-[DN]-x-D-C-x(3)-C-x-C
                    [The 5 C's are involved in disulfide bonds]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: May 2004 / Text revised.

[ 1] Otlewski J.
     "The squash inhibitor family of serine proteinases."
     Biol. Chem. Hoppe-Seyler 371:23-28(1990).
     PubMed=2205236

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