{PDOC00265}
{PS01251; PCNA_1}
{PS00293; PCNA_2}
{BEGIN}
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* Proliferating cell nuclear antigen signatures *
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Proliferating cell  nuclear  antigen (PCNA) [1,2] is a protein involved in DNA
replication  by  acting  as a    cofactor    for    DNA  polymerase delta, the
polymerase responsible for lagging strand DNA replication.

A similar protein exists  in  yeast (gene POL30) [3]  and is  associated  with
polymerase III, the yeast analog of polymerase delta.   In  baculoviruses  the
ETL protein has  been shown [4] to  be highly related  to PCNA and is probably
associated with the viral encoded DNA polymerase. An homolog  of  PCNA is also
found in archebacteria.

As signatures for this family of proteins, we selected a two conserved regions
located in  the  N-terminal  section. The second one has been proposed to bind
DNA.

-Consensus pattern: [GSTA]-[LIVMF]-x-[LIVMAS]-x-[GSAVI]-[LIVM]-[DS]-x-[NSAED]-
                    [HKRNS]-[VIT]-x-[LMYF]-[VIGAL]-x-[LIVMF]-x-[LIVM]-x(4)-F
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Consensus pattern: [RKA]-C-[DE]-[RH]-x(3)-[LIVMF]-x(3)-[LIVM]-x-[SGAN]-
                    [LIVMF]-x-K-[LIVMF](2)
-Sequences known to belong to this class detected by the pattern: ALL,  except
 for archaebacterial PCNA homologs.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: January 2012 / Text revised.

[ 1] Bravo R., Frank R., Blundell P.A., Mcdonald-Bravo H.
     "Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta."
     Nature 326:515-517(1987).
     PubMed=2882423; DOI=10.1038/326515a0
[ 2] Suzuka I., Hata S., Matsuoka M., Kosugi S., Hashimoto J.
     "Highly conserved structure of proliferating cell nuclear antigen (DNA
     polymerase delta auxiliary protein) gene in plants."
     Eur. J. Biochem. 195:571-575(1991).
     PubMed=1671766
[ 3] Bauer G.A., Burgers P.M.J.
     "Molecular cloning, structure and expression of the yeast
     proliferating cell nuclear antigen gene."
     Nucleic Acids Res. 18:261-265(1990).
     PubMed=1970160
[ 4] O'Reilly D.R., Crawford A.M., Miller L.K.
     Nature 337:606-606(1989).

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