{PDOC00281} {PS00312; GLYCOPHORIN_A} {BEGIN} *************************** * Glycophorin A signature * *************************** Glycophorin A is the major sialoglycoprotein of erythrocyte membrane [1]. Structurally, glycophorin A consists of an N-terminal extracellular domain, heavily glycosylated on serine and threonine residues, followed by a transmembrane region and a C-terminal cytoplasmic domain. In human there are two closely related forms: glycophorin A which carries the blood group M/N antigen, and glycophorin B which carries the blood group S/s antigen. The best conserved region of glycophorin A is the transmembrane domain and we have derived a consensus pattern from that region. -Consensus pattern: I-I-x-[GAC]-V-M-A-G-[LIVM](2) -Sequences known to belong to this class detected by the pattern: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: December 1991 / Pattern and text revised. [ 1] Murayama J.-I., Utsumi H., Hamada A. "Amino acid sequence of monkey erythrocyte glycophorin MK. Its amino acid sequence has a striking homology with that of human glycophorin A." Biochim. Biophys. Acta 999:273-280(1989). PubMed=2605264 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}