{PDOC00290}
{PS00326; TROPOMYOSIN}
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* Tropomyosins signature *
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Tropomyosins [1,2] are family of closely  related  proteins  present in muscle
and non-muscle cells. In striated muscle, tropomyosin mediate the interactions
between the  troponin  complex and actin so as to regulate muscle contraction.
The role of tropomyosin in smooth muscle  and non-muscle tissues is not clear.
Tropomyosin is an alpha-helical protein that forms a coiled-coil dimer.

Muscle isoforms of tropomyosin are  characterized  by  having  284  amino acid
residues and a highly  conserved N-terminal  region,  whereas non-muscle forms
are generally smaller and are heterogeneous in their N-terminal region.

The signature pattern for tropomyosins  is based on a very conserved region in
the C-terminal section of tropomyosins and which is present in both muscle and
non-muscle forms.

-Consensus pattern: L-K-[EAD]-A-E-x-R-A-[ET]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2004 / Pattern and text revised.

[ 1] Smilie L.B.
     Trends Biochem. Sci. 4:151-155(1979).
[ 2] McLeod A.R.
     BioEssays 6:208-212(1986).

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