{PDOC00296}
{PS00335; PARATHYROID}
{BEGIN}
****************************************
* Parathyroid hormone family signature *
****************************************

Parathyroid hormone (PTH)  is  a  polypeptidic  hormone  that elevates calcium
level  by  dissolving  the salts in bone and preventing their renal excretion.
PTH is a protein of about 80 amino acid  residues, but its biological activity
seems to be contained within the first 34 residues.

PTH is structurally related  to  a protein called 'parathyroid hormone-related
protein' (PTH-rP) [1]  which seems to play a  physiological role in lactation,
possibly as a hormone  for the  mobilization and/or transfer of calcium to the
milk.  PTH-rP is  a  protein  of  141  amino  acids.  As for PTH, the first 34
residues are sufficient to mediate the biological activity of PTH-rP.  PTH and
PTH-rP bind to the same G-protein coupled receptor.

The signature pattern we selected for these proteins is derived from conserved
residues in the N-terminal extremity of PTH and PTH-rP, spanning residues 2 to
12.

-Consensus pattern: V-S-E-x-Q-x(2)-H-x(2)-G
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: June 1992 / Text revised.

[ 1] Martin T.J., Allan E.H., Caple I.W., Care A.D., Danks J.A.,
     Diefenbach-Jagger H., Ebeling P.R., Gillepsie M.T., Hammonds G.,
     Heath J.A., Hudson P.J., Kemp B.E., Kubota M., Kukreja S.C.,
     Moseley J.M., Ng K.W., Raisz L.G., Rodda C.P., Simmons H.A., Suva L.J.,
     Wettenhall R.E.H., Wood W.I.
     "Parathyroid hormone-related protein: isolation, molecular cloning,
     and mechanism of action."
     Recent Prog. Horm. Res. 45:467-502(1989).
     PubMed=2682846;

--------------------------------------------------------------------------------
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html
--------------------------------------------------------------------------------

{END}