{PDOC00308} {PS00357; HISTONE_H2B} {BEGIN} ************************* * Histone H2B signature * ************************* Histone H2B is one of the four histones, along with H2A, H3 and H4, which forms the eukaryotic nucleosome core. Using alignments of histone H2B sequences [1,2,E1], we selected a conserved region in the C-terminal part of H2B. -Consensus pattern: [KR]-E-[LIVM]-[EQ]-T-x(2)-[KR]-x-[LIVM](2)-x-[PAG]-[DE]-L- x-[KR]-H-A-[LIVM]-[STA]-E-G -Sequences known to belong to this class detected by the pattern: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: November 1995 / Pattern and text revised. [ 1] Wells D.E., Brown D. "Histone and histone gene compilation and alignment update." Nucleic Acids Res. 19:2173-2188(1991). PubMed=2041803 [ 2] Thatcher T.H., Gorovsky M.A. "Phylogenetic analysis of the core histones H2A, H2B, H3, and H4." Nucleic Acids Res. 22:174-179(1994). PubMed=8121801 [E1] https://www.ncbi.nlm.nih.gov/projects/HistoneDB2.0/index.fcgi/browse/ -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}