{PDOC00315} {PS00366; URICASE} {BEGIN} ********************* * Uricase signature * ********************* Uricase (EC 1.7.3.3) (urate oxidase) [1] is the peroxisomal enzyme responsible for the degradation of urate into allantoin. Some species, like primates and birds, have lost the gene for uricase and are therefore unable to degrade urate. Uricase is a protein of 300 to 400 amino acids, its sequence is well conserved and we have used, as a signature pattern, a highly conserved region located in the central part of the sequence. -Consensus pattern: [LV]-x-[LV]-[LIV]-K-[STV]-[ST]-x-[SN]-x-F-x(2)-[FY]-x(4)- [FY]-x(2)-L-x(5)-R -Sequences known to belong to this class detected by the pattern: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: July 1999 / Pattern and text revised. [ 1] Motojima K., Kanaya S., Goto S. "Cloning and sequence analysis of cDNA for rat liver uricase." J. Biol. Chem. 263:16677-16681(1988). PubMed=3182808 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}