{PDOC00349}
{PS00424; INTERLEUKIN_2}
{BEGIN}
***************************
* Interleukin-2 signature *
***************************

Interleukin-2 (IL-2)  [1,2]  is  a  cytokine  produced    by T-helper cells in
response to  antigenic  or mitogenic stimulation. This protein is required for
T-cell proliferation  and  other  activities  crucial to the regulation of the
immune response.

The mature  form  of  IL-2,  after  cleavage  of  the  signal  sequence,  is a
glycoprotein of about  130 amino acids that  contains a single disulfide bond.
A schematic representation of this structure is shown below.

                              *******
        xTxxxxxxxxxxxxxxxxxxxxxxxxCxxxxxxxxxxxxxxxxxxxxxxCxxxxxxxxxxxxxx
         |                        |                      |
         Sugar                    +----------------------+

'C': conserved cysteine involved in a disulfide bond.
'*': position of the pattern.

-Consensus pattern: T-E-[LF]-x(2)-L-x-C-L-x(2)-E-L
                    [C is involved in a disulfide bond]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: July 1998 / Pattern and text revised.

[ 1] Smith K.A.
     "Interleukin-2: inception, impact, and implications."
     Science 240:1169-1176(1988).
     PubMed=3131876
[ 2] Mizel S.B.
     "The interleukins."
     FASEB J. 3:2379-2388(1989).
     PubMed=2676681

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