{PDOC00367}
{PS00400; LBP_BPI_CETP}
{BEGIN}
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* LBP / BPI / CETP family signature *
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The following  mammalian  lipid-binding serum glycoproteins belong to the same
family [1,2,3]:

 - Lipopolysaccharide-binding protein (LBP).  LBP binds to the lipid A  moiety
   of bacterial lipopolysaccharides (LPS), a glycolipid present  in  the outer
   membrane of  all  Gram-negative bacteria.  The  LBP/LPS  complex  seems  to
   interact with the CD14 receptor and may be responsible for the secretion of
   alpha-TNF.
 - Bactericidal permeability-increasing protein (BPI). Like LBP, BPI binds LPS
   and has a cytotoxic activity on Gram-negative bacteria.
 - Cholesteryl ester transfer protein (CETP). CETP is involved in the transfer
   of insoluble cholesteryl esters in reverse cholesterol transport.
 - Phospholipid  transfer protein (PLTP). May play a key role in extracellular
   phospholipid transport and modulation of HDL particles.

These proteins are structurally related  and  share  many  regions of sequence
similarities.  As a signature pattern  we  have selected one of these regions,
which is located in  the N-terminal  section of these proteins; a region which
could be involved in the binding to the lipids [2].

-Consensus pattern: [PA]-[GA]-[LIVMC]-x(2)-R-[IV]-[ST]-x(3)-L-x(5)-[EQAV]-
                    x(4)-[LIVM]-[EQK]-x(8)-P
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Expert(s) to contact by email:
           Jongeneel C.V.; victor.jongeneel@isrec.unil.ch

-Last update: December 2004 / Pattern and text revised.

[ 1] Schumann R.R., Leong S.R., Flaggs G.W., Gray P.W., Wright S.D.,
     Mathison J.C., Tobias P.S., Ulevitch R.J.
     "Structure and function of lipopolysaccharide binding protein."
     Science 249:1429-1431(1990).
     PubMed=2402637;
[ 2] Gray P.W., Flaggs G., Leong S.R., Gumina R.J., Weiss J., Ooi C.E.,
     Elsbach P.
     "Cloning of the cDNA of a human neutrophil bactericidal protein.
     Structural and functional correlations."
     J. Biol. Chem. 264:9505-9509(1989).
     PubMed=2722846;
[ 3] Day J.R., Albers J.J., Lofton-Day C.E., Gilbert T.L., Ching A.F.T.,
     Grant F.J., O'Hara P.J., Marcovina S.M., Adolphson J.L.
     "Complete cDNA encoding human phospholipid transfer protein from human
     endothelial cells."
     J. Biol. Chem. 269:9388-9391(1994).
     PubMed=8132678;

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