{PDOC00369}
{PS00376; ADOMET_SYNTHASE_1}
{PS00377; ADOMET_SYNTHASE_2}
{BEGIN}
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* S-adenosylmethionine synthase signatures *
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S-adenosylmethionine synthase  (EC  2.5.1.6)  is the enzyme that catalyzes the
formation of S-adenosylmethionine (AdoMet) from methionine and ATP [1]. AdoMet
is an important  methyl donor for transmethylation and is also the propylamino
donor in polyamine biosynthesis.

In bacteria  there  is  a single isoform of AdoMet synthase (gene metK), there
are two  in budding yeast (genes SAM1 and SAM2) and in mammals while in plants
there is generally a multigene family.

The sequence  of  AdoMet  synthase is highly conserved throughout isozymes and
species. We selected two signature patterns for this type of enzyme; the first
is a  hexapeptide  which seems to be involved in ATP-binding; the second is an
almost perfectly conserved glycine-rich nonapeptide.

-Consensus pattern: [GN]-[AS]-G-D-Q-G-x(3)-G-[FYHG]
-Sequences known to belong to this class detected by the pattern: ALL,  except
 for M.genitalium metK.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Consensus pattern: G-[GA]-G-[ASC]-[FY]-S-x-K-[DE]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: April 2006 / Pattern revised.

[ 1] Horikawa S., Sasuga J., Shimizu K., Ozasa H., Tsukada K.
     "Molecular cloning and nucleotide sequence of cDNA encoding the rat
     kidney S-adenosylmethionine synthetase."
     J. Biol. Chem. 265:13683-13686(1990).
     PubMed=1696256

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