{PDOC00381}
{PS00434; HSF_DOMAIN}
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* HSF-type DNA-binding domain signature *
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Heat shock factor (HSF) is a DNA-binding protein  that specifically binds heat
shock  promoter  elements (HSE).  HSE  is  a  palindromic  element  rich  with
repetitive purine and  pyrimidine motifs:  5'-nGAAnnTTCnnGAAnnTTCn-3'.  HSF is
expressed at normal  temperatures but is  activated  by heat shock or chemical
stressors [1,2]. The sequences  of  HSF  from  various  species show extensive
similarity in  a  region  of about 90 amino acids, which has been shown [3] to
bind DNA.

Some other proteins also contain a HSF domain, these are:

 - Yeast  SFL1,  a protein involved in cell surface assembly and regulation of
   the gene related to flocculation (asexual cell aggregation) [4].
 - Yeast  transcription  factor  SKN7  (or  BRY1  or POS9), which binds to the
   promoter elements  SCB  and  MCB  essential  for the controal of G1 cyclins
   expression [5].
 - Yeast MGA1.
 - Yeast hypothetical protein YJR147w.

We have  derived a pattern from the most conserved part of the HSF DNA-binding
domain, its central region.

-Consensus pattern: L-x(3)-[FY]-K-H-x-N-x-[STAN]-S-F-[LIVM]-R-Q-L-[NH]-x-Y-x-
                    [FYW]-[RKH]-K-[LIVM]
-Sequences known to belong to this class detected by the pattern: ALL,  except
 for YJR147w whose sequence in the HSF domain is quite divergent.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: November 1997 / Pattern and text revised.

[ 1] Sorger P.K.
     "Heat shock factor and the heat shock response."
     Cell 65:363-366(1991).
     PubMed=2018972
[ 2] Mager W.H., Moradas Ferreira P.M.
     "Stress response of yeast."
     Biochem. J. 290:1-13(1993).
     PubMed=8439279
[ 3] Vuister G.W., Kim S.-J., Orosz A., Marquardt J., Wu C., Bax A.
     "Solution structure of the DNA-binding domain of Drosophila heat shock
     transcription factor."
     Nat. Struct. Biol. 1:605-614(1994).
     PubMed=7634100
[ 4] Fujita A., Kikuchi Y., Kuhara S., Misumi Y., Matsumoto S., Kobayashi H.
     "Domains of the SFL1 protein of yeasts are homologous to Myc
     oncoproteins or yeast heat-shock transcription factor."
     Gene 85:321-328(1989).
     PubMed=2697640
[ 5] Morgan B.A., Bouquin N., Merrill G.F., Johnston L.H.
     "A yeast transcription factor bypassing the requirement for SBF and
     DSC1/MBF in budding yeast has homology to bacterial signal
     transduction proteins."
     EMBO J. 14:5679-5689(1995).
     PubMed=8521825

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