{PDOC00385} {PS00474; RIBOSOMAL_L3} {BEGIN} ********************************** * Ribosomal protein L3 signature * ********************************** Ribosomal protein L3 is one of the proteins from the large ribosomal subunit. In Escherichia coli, L3 is known to bind to the 23S rRNA and may participate in the formation of the peptidyltransferase center of the ribosome. It belongs to a family of ribosomal proteins which, on the basis of sequence similarities [1,2,3,4], groups: - Eubacterial L3. - Red algal L3. - Cyanelle L3. - Archaebacterial Halobacterium marismortui HmaL3 (HL1). - Yeast L3 (also known as trichodermin resistance protein) (gene TCM1). - Arabidopsis thaliana L3 (genes ARP1 and ARP2). - Mammalian L3 (L4). - Mammalian mitochondrial L3. - Yeast mitochondrial YmL9 (gene MRPL9). As a signature pattern, we selected a conserved region located in the central section of these proteins. -Consensus pattern: [FL]-x(6)-[DN]-x(2)-[AGS]-x-[ST]-x-G-[KRH]-G-x(2)-G-x(3)-R -Sequences known to belong to this class detected by the pattern: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: November 1997 / Pattern and text revised. [ 1] Arndt E., Kroemer W., Hatakeyama T. "Organization and nucleotide sequence of a gene cluster coding for eight ribosomal proteins in the archaebacterium Halobacterium marismortui." J. Biol. Chem. 265:3034-3039(1990). PubMed=2406244 [ 2] Graack H.-R., Grohmann L., Kitakawa M., Schaefer K.L., Kruft V. "YmL9, a nucleus-encoded mitochondrial ribosomal protein of yeast, is homologous to L3 ribosomal proteins from all natural kingdoms and photosynthetic organelles." Eur. J. Biochem. 206:373-380(1992). PubMed=1597181 [ 3] Herwig S., Kruft V., Wittmann-Liebold B. "Primary structures of ribosomal proteins L3 and L4 from Bacillus stearothermophilus." Eur. J. Biochem. 207:877-885(1992). PubMed=1499563 [ 4] Otaka E., Hashimoto T., Mizuta K., Suzuki K. Protein Seq. Data Anal. 5:301-313(1993). -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}