{PDOC00390}
{PS00461; 6PGD}
{BEGIN}
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* 6-phosphogluconate dehydrogenase signature *
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6-phosphogluconate dehydrogenase (EC 1.1.1.44) (6PGD) catalyzes the third step
in  the  hexose   monophosphate   shunt,   the  decarboxylating  reduction  of
6-phosphogluconate in to ribulose 5-phosphate.

Prokaryotic and  eukaryotic 6PGD  are  proteins of about 470 amino acids whose
sequence are highly conserved [1].  As a  signature pattern we have selected a
region which has been shown [2],  from  studies  of  the  sheep  6PGD tertiary
structure, to be involved in the binding of 6-phosphogluconate.

-Consensus pattern: [LIVM]-x-[DG]-x(2)-[GAEHS]-[NQSD]-[KS]-G-[TE]-G-x-W
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: December 2004 / Pattern and text revised.

[ 1] Reizer A., Deutscher J., Saier M.H. Jr., Reizer J.
     "Analysis of the gluconate (gnt) operon of Bacillus subtilis."
     Mol. Microbiol. 5:1081-1089(1991).
     PubMed=1659648
[ 2] Adams M.J., Archibald I.G., Bugg C.E., Carne A., Gover S.,
     Helliwell J.R., Pickersgill R.W., White S.W.
     "The three dimensional structure of sheep liver 6-phosphogluconate
     dehydrogenase at 2.6 A resolution."
     EMBO J. 2:1009-1014(1983).
     PubMed=6641716

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