{PDOC00397}
{PS00494; BACTERIAL_LUCIFERASE}
{BEGIN}
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* Bacterial luciferase subunits signature *
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Luminous bacteria  are  abundant and  widely distributed  Gram-negative motile
rods. The enzyme responsible for bioluminescence, bacterial luciferase [1,2,3]
(EC 1.14.14.3),  catalyzes  the  oxidation  of  reduced  riboflavin  phosphate
(FMNH2) and  a long chain fatty aldehyde with the emission of blue green light
(490 nm).  Luciferase  is  a heterodimeric enzyme composed of an alpha subunit
(gene luxA)  and a beta subunit (gene luxB).  The  two subunits appear to have
arisen by gene duplication.

The bioluminescence operon of some species of Photobacterium encodes a protein
known as  the  non-fluorescent  flavoprotein  (NFP)  (gene  luxF).  NFP, whose
function is not yet known, contains an unusual non-covalently bound flavin. It
is evolutionary related to the luxA/luxB subunits.

As a signature for this family, we selected  a conserved region located in the
central part of these proteins.

-Consensus pattern: [GA]-[LIVM]-P-[LIVM]-x-[LIVMFY]-x-W-x(6)-[RK]-x(6)-Y-x(3)-
                    [AR]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: June 1994 / Text revised.

[ 1] Meighen E.A.
     "Molecular biology of bacterial bioluminescence."
     Microbiol. Rev. 55:123-142(1991).
     PubMed=2030669
[ 2] Meighen E.A.
     "Bacterial bioluminescence: organization, regulation, and application
     of the lux genes."
     FASEB J. 7:1016-1022(1993).
     PubMed=8370470
[ 3] O'Kane D.J.O., Prasher D.C.
     Mol. Microbiol. 6:443-449(1992).

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