{PDOC00432}
{PS00473; GNRH}
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* Gonadotropin-releasing hormones signature *
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The gonadotropin-releasing hormones (GnRH) (gonadoliberin) [1] are a family of
peptides that  play  a pivotal role in reproduction. The main function of GnRH
is to  act  on  the  pituitary  to  stimulate  the  synthesis and secretion of
luteinizing  and  follicle-stimulating  hormones, but  GnRH  also  acts on the
brain, retina,  sympathetic  nervous  system, gonads  and  placenta in certain
species. There  seems  to  be at least three forms of GnRH. The second form is
expressed in midbrain and seems to be widespread. The third form has only been
found so far in fish.

GnRH is  a C-terminal  amidated  decapeptide processed from a larger precursor
protein. Four  of  the  ten  residues  are perfectly  conserved in all species
where GnRH has been sequenced.

-Consensus pattern: Q-[HY]-[FYW]-S-x(4)-P-G
                    [G is amidated]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Expert(s) to contact by email:
           Eisen J.A.; jeisen@tigr.org

-Last update: July 1999 / Pattern and text revised.

[ 1] Sherwood N.
     Trends Neurosci. 10:129-132(1987).

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