{PDOC00446}
{PS00515; SVP_II}
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* Seminal vesicle protein II repeats signature *
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Seminal vesicle  protein II (SVP-II) [1] is  one  of  the six  major secretory
proteins secreted by rat seminal vesicle. It is a clotting protein that serves
as the substrate in the  formation of the copulatory plug.  Covalent  clotting
of this protein is catalyzed by a transglutaminase and involves  the formation
of gamma-glutamyl-epsilon-lysine crosslinks. SVS-II sequence contains thirteen
repeats of a thirteen amino acid  residue domain which is probably involved in
the cross-linking.  There  are a  number of invariant residues in this domain,
four of them  (two lysines and two glutamines)  probably  participate  in  the
cross-links.  The pattern we have developed comprises positions 2 to 12 of the
domain and includes the four putative cross-linking residues.

-Consensus pattern: [GSA]-Q-x-K-S-[FY]-x-Q-x-K-[SA]
                    [The 2 Q's and the 2 K's are probably involved in cross-links]
-Sequences known to belong to this class detected by the pattern: ALL; it will
 detect 12 of the 13 occurrences of the repeat.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: May 2004 / Text revised.

[ 1] Harris S.E., Harris M.A., Johnson C.M., Bean M.F., Dodd J.G.,
     Matusik R.J., Carr S.A., Crabb J.W.
     "Structural characterization of the rat seminal vesicle secretion II
     protein and gene."
     J. Biol. Chem. 265:9896-9903(1990).
     PubMed=2351680

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