{PDOC00448} {PS00517; RNASE_3_1} {PS50142; RNASE_3_2} {BEGIN} ************************************************* * Ribonuclease III family signature and profile * ************************************************* Prokaryotic ribonuclease III (EC 3.1.26.3) (gene rnc) [1] is an enzyme that digests double-stranded RNA. It is involved in the processing of ribosomal RNA precursors and of some mRNAs. RNase III is evolutionary related [2] to the following proteins: - Fission yeast pac1, a ribonuclease that probably inhibits mating and meiosis by degrading a specific mRNA required for sexual development. - Yeast ribonuclease III (gene RNT1), a dsRNA-specific nuclease that cleaves eukaryotic preribosomal RNA at various sites. - Caenorhabditis elegans hypothetical protein F26E4.13. - Paramecium bursaria chlorella virus 1 protein A464R. - Synechocystis strain PCC 6803 hypothetical protein slr0346. - Fission yeast hypothetical protein SpAC8A4.08c, a protein with a N-terminal helicase domain and a C-terminal RNase III domain. - Caenorhabditis elegans hypothetical protein K12H4.8, a protein with the same structure as SpAC8A4.08c. These proteins share regions of sequence similarity; one of which is a highly conserved stretch of 9 residues which we use as a signature pattern. -Consensus pattern: [DEQ]-[KRQT]-[LMF]-E-[FYW]-[LV]-G-D-[SARHG] -Sequences known to belong to this class detected by the pattern: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Sequences known to belong to this class detected by the profile: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: December 2004 / Pattern and text revised. [ 1] Nashimoto H., Uchida H. "DNA sequencing of the Escherichia coli ribonuclease III gene and its mutations." Mol. Gen. Genet. 201:25-29(1985). PubMed=3903434 [ 2] Mian I.S. "Comparative sequence analysis of ribonucleases HII, III, II PH and D." Nucleic Acids Res. 25:3187-3195(1997). PubMed=9241229 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}