{PDOC00451}
{PS00521; P5CR}
{BEGIN}
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* Delta 1-pyrroline-5-carboxylate reductase signature *
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Delta 1-pyrroline-5-carboxylate reductase  (P5CR)  (EC 1.5.1.2) [1,2]  is  the
enzyme that    catalyzes the terminal step in the biosynthesis of proline from
glutamate, the NAD(P)  dependent oxidation  of  1-pyrroline-5-carboxylate into
proline.

The sequences  of  P5CR   from  eubacteria  (gene  proC),  archaebacteria  and
eukaryotes show  only  a  moderate level of overall similarity. As a signature
pattern, we  selected  the  best  conserved  region  located in the C-terminal
section of P5CR.

-Consensus pattern: [PALF]-x(2,3)-[LIV]-x(3)-[LIVM]-[STAC]-[STV]-x-[GANK]-G-x-
                    T-x(2)-[AG]-[LIV]-x(2)-[LMF]-[DENQK]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2004 / Pattern and text revised.

[ 1] Delauney A.J., Verma D.P.
     "A soybean gene encoding delta 1-pyrroline-5-carboxylate reductase was
     isolated by functional complementation in Escherichia coli and is
     found to be osmoregulated."
     Mol. Gen. Genet. 221:299-305(1990).
     PubMed=2199815
[ 2] Savioz A., Jeenes D.J., Kocher H.P., Haas D.
     "Comparison of proC and other housekeeping genes of Pseudomonas
     aeruginosa with their counterparts in Escherichia coli."
     Gene 86:107-111(1990).
     PubMed=2107123

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