{PDOC00475}
{PS00549; BACTERIOFERRITIN}
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* Bacterioferritin signature *
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Bacterioferritin (BFR) [1,2] is  a prokaryotic iron-storing protein  that  may
perform analogous functions in  iron detoxification and  storage  as  that  of
eukaryotic ferritins. BFR is also known as cytochrome b-1, b-557, b-557.5,  or
b-559 in various bacterial species.

BFR is an oligomer composed of 24 identical  subunits  that contains protoheme
IX in addition to the non-heme iron core.  The  two axial ligands for the heme
group iron have been shown [3] to be methionine residues.

As a signature pattern we selected the conserved N-terminal extremity of BFR.

-Consensus pattern: <M-x-G-x(3)-[IV]-[LIV]-x(2)-[LM]-x(3)-L-x(3)-L
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2001 / Pattern and text revised.

[ 1] Andrews S.C., Smith J.M.A., Guest J.R., Harrison P.M.
     "Genetic and structural characterization of the bacterioferritin of
     Escherichia coli."
     Biochem. Soc. Trans. 18:658-659(1990).
     PubMed=2276500
[ 2] Andrews S.C., Findlay J.B.C., Guest J.R., Harrison P.M., Keen J.N.,
     Smith J.M.A.
     "Physical, chemical and immunological properties of the
     bacterioferritins of Escherichia coli, Pseudomonas aeruginosa and
     Azotobacter vinelandii."
     Biochim. Biophys. Acta 1078:111-116(1991).
     PubMed=1904771
[ 3] Cheesman M.R., Thomson A.J., Greenwood C., Moore G.R., Kadir F.
     "Bis-methionine axial ligation of haem in bacterioferritin from
     Pseudomonas aeruginosa."
     Nature 346:771-773(1990).
     PubMed=2167456; DOI=10.1038/346771a0

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