{PDOC00479}
{PS00554; TEA_1}
{PS51088; TEA_2}
{BEGIN}
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* TEA domain signature and profile *
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The TEA  domain is a DNA-binding region of ~80 amino acids that has been named
after the  two proteins that originally defined the domain: TEF-1 and AbaA. It
is also  referred  to as the ATTS domain because of the 4 proteins first found
to harbor  this  motif  (AbaA and TEC1 in yeast, TEF1/TEAD1 in vertebrates and
Scalloped in  fly).  The  TEA  domain  is located toward the amino terminus of
eukaryotic  transcription  factors of  the  TEA/ATTS family. The consensus DNA
sequence bound  by  an  isolated TEA domain is N-[ATG]-G-[ATC]-A-T-N-T; where,
N=A, T, C. or G [1,2,3,4].

The TEA  domain  is  composed  of a three-helix bundle with a homeodomain fold
(see <PDB:2HZD>).  It  has  a  folded  globular structure made of three alpha-
helices, H1, H2, and H3. H1 and H2 are nearly anti-parallel and pack on either
side of  the  H3,  which  is  the DNA-recognition helix of the TEA domain. Two
conserved serines are found on the DNA-binding surface. Phosphorylation of one
or both  of  these  could  interfere with DNA-binding activity, by introducing
electrostatic repulsion  and/or  steric  hindrance, and help regulate TEA/ATTS
transcription factor activity [3,4].

Some of the proteins that contain a TEA domain are listed below:

 - Mammalian enhancer factor TEF-1. TEF-1 can bind to two  distinct  sequences
   in the SV40 enhancer and is a transcriptional activator.
 - Mammalian  TEF-3,  TEF-4 and TEF-5 [5], putative transcriptional activators
   highly similar to TEF-1.
 - Drosophila scalloped protein (gene sd),  a  probable  transcription  factor
   that functions in the regulation  of cell-specific gene  expression  during
   Drosophila development, particularly  in the differentiation of the nervous
   system [6].
 - Emericella nidulans  regulatory  protein  abaA.  AbaA  is  involved  in the
   regulation  of conidiation (asexual spore);  its expression  leads  to  the
   cessation of vegetative growth.
 - Yeast trans-acting factor TEC1.  TEC1  is involved in the activation of the
   Ty1 retrotransposon.
 - Caenorhabditis elegans hypothetical protein F28B12.2.

We developed  both  a pattern and a profile. The pattern covers helices H2 and
H3, whereas the profile covers the whole domain.

-Consensus pattern: G-R-N-E-L-I-x(2)-[YH]-I-x(3)-[TC]-x(3)-R-T-[RK](2)-Q-
                    [LIVM]-S-S-H-[LIVM]-Q-V
-Sequences known to belong to this class detected by the pattern: ALL,  except
 for 4 sequences.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: January 2017 / Profile and text revised.

[ 1] Buerglin T.R.
     "The TEA domain: a novel, highly conserved DNA-binding motif."
     Cell 66:11-12(1991).
     PubMed=2070413
[ 2] Hwang J.J., Chambon P., Davidson I.
     "Characterization of the transcription activation function and the DNA
     binding domain of transcriptional enhancer factor-1."
     EMBO J. 12:2337-2348(1993).
     PubMed=8389695
[ 3] Anbanandam A., Albarado D.C., Nguyen C.T., Halder G., Gao X.,
     Veeraraghavan S.
     "Insights into transcription enhancer factor 1 (TEF-1) activity from
     the solution  structure of the TEA domain."
     Proc. Natl. Acad. Sci. U.S.A. 103:17225-17230(2006).
     PubMed=17085591; DOI=10.1073/pnas.0607171103
[ 4] Landin-Malt A., Benhaddou A., Zider A., Flagiello D.
     "An evolutionary, structural and functional overview of the mammalian
     TEAD1 and TEAD2 transcription factors."
     Gene 591:292-303(2016).
     PubMed=27421669; DOI=10.1016/j.gene.2016.07.028
[ 5] Jacquemin P., Hwang J.-J., Martial J.A., Dolle P., Davidson I.
     "A novel family of developmentally regulated mammalian transcription
     factors containing the TEA/ATTS DNA binding domain."
     J. Biol. Chem. 271:21775-21785(1996).
     PubMed=8702974
[ 6] Campbell S., Inamdar M., Rodrigues V., Raghavan V., Palazzolo M.,
     Chovnick A.
     "The scalloped gene encodes a novel, evolutionarily conserved
     transcription factor required for sensory organ differentiation in
     Drosophila."
     Genes Dev. 6:367-379(1992).
     PubMed=1547938

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