{PDOC00483}
{PS00558; EUKARYOTIC_PORIN}
{BEGIN}
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* Eukaryotic mitochondrial porin signature *
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The major  protein  of the outer  mitochondrial  membrane  of  eukaryotes is a
porin  that  forms a  voltage-dependent  anion-selective  channel (VDAC)  that
behaves as a general diffusion pore for  small hydrophilic molecules [1 to 4].
The channel adopts an open conformation at low  or zero membrane potential and
a closed conformation at potentials above 30-40 mV.

This protein  contains  about  280 amino acids and its sequence is composed of
between 12  to  16  beta-strands  that  span the mitochondrial outer membrane.
Yeast  contains two members of this family (genes POR1 and POR2);  vertebrates
have at least three members (genes VDAC1, VDAC2 and VDAC3) [5].

As a  signature  pattern  we  selected  a  conserved  region located at the C-
terminal part of these proteins.

-Consensus pattern: [YH]-x(2)-D-[SPCAD]-x-[STA]-x(3)-[TAG]-[KR]-[LIVMF]-
                    [DNSTA]-[DNS]-x(4)-[GSTAN]-[LIVMA]-x-[LIVMY]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: July 1999 / Pattern and text revised.

[ 1] Benz R.
     "Permeation of hydrophilic solutes through mitochondrial outer
     membranes: review on mitochondrial porins."
     Biochim. Biophys. Acta 1197:167-196(1994).
     PubMed=8031826
[ 2] Manella C.A.
     Trends Biochem. Sci. 17:315-320(1992).
[ 3] Dihanich M.
     "The biogenesis and function of eukaryotic porins."
     Experientia 46:146-153(1990).
     PubMed=1689252
[ 4] Forte M., Guy H.R., Mannella C.A.
     "Molecular genetics of the VDAC ion channel: structural model and
     sequence analysis."
     J. Bioenerg. Biomembr. 19:341-350(1987).
     PubMed=2442148
[ 5] Sampson M.J., Lovell R.S., Davison D.B., Craigen W.J.
     "A novel mouse mitochondrial voltage-dependent anion channel gene
     localizes to chromosome 8."
     Genomics 36:192-196(1996).
     PubMed=8812436

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