{PDOC00500}
{PS00578; RIBOSOMAL_S6E}
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* Ribosomal protein S6e signature *
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A number of eukaryotic  and  archaebacterial ribosomal proteins can be grouped
on the basis of sequence similarities. One of these families consists of:

 - Mammalian S6 [1].
 - Drosophila S6 [2].
 - Plant S6 [3].
 - Yeast S10 (YS4).
 - Halobacterium marismortui HS13 [4].
 - Methanococcus jannaschii MJ1260.

S6 is  the major substrate of protein kinases in eukaryotic ribosomes [5];  it
may have  an  important  role  in  controlling  cell growth  and proliferation
through the selective translation of particular classes of mRNA.

These proteins  have  135  to  249  amino  acids.  As  a signature pattern, we
selected a conserved  stretch  of 12 residues  in the N-terminal part of these
proteins.

-Consensus pattern: [LIVM]-[STAMR]-G-G-x-[DG]-x(2)-G-x-[PV]-M
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Expert(s) to contact by email:
           Thomas G.; gthomas@fmi.ch

-Last update: December 2004 / Pattern and text revised.

[ 1] Franco R., Rosenfeld M.G.
     "Hormonally inducible phosphorylation of a nuclear pool of ribosomal
     protein S6."
     J. Biol. Chem. 265:4321-4325(1990).
     PubMed=2106518
[ 2] Watson K.L., Konrad K.D., Woods D.F., Bryant P.J.
     "Drosophila homolog of the human S6 ribosomal protein is required for
     tumor suppression in the hematopoietic system."
     Proc. Natl. Acad. Sci. U.S.A. 89:11302-11306(1992).
     PubMed=1454811
[ 3] Hansen G., Estruch J.J., Spena A.
     "Tobacco cDNA encoding the ribosomal protein S6."
     Nucleic Acids Res. 20:5230-5230(1992).
     PubMed=1408841
[ 4] Kimura M., Arndt E., Hatakeyama T., Hatakeyama T., Kimura J.
     "Ribosomal proteins in halobacteria."
     Can. J. Microbiol. 35:195-199(1989).
     PubMed=2655851
[ 5] Bandi H.R., Ferrari S., Krieg J., Meyer H.E., Thomas G.
     "Identification of 40 S ribosomal protein S6 phosphorylation sites in
     Swiss mouse 3T3 fibroblasts stimulated with serum."
     J. Biol. Chem. 268:4530-4533(1993).
     PubMed=8440735

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