{PDOC00534}
{PS00611; HISOL_DEHYDROGENASE}
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* Histidinol dehydrogenase signature *
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Histidinol dehydrogenase (EC 1.1.1.23) (HDH) catalyzes  the  terminal  step in
the  biosynthesis of  histidine  in  bacteria,  fungi,  and  plants, the four-
electron oxidation of L-histidinol to histidine.

In bacteria HDH is a single chain  polypeptide;  in fungi it is the C-terminal
domain of a multifunctional  enzyme which  catalyzes three  different steps of
histidine biosynthesis;  and  in  plants it is  expressed as  nuclear  encoded
protein precursor which is exported to the chloroplast [1].

As a  signature  pattern  we selected a highly conserved region located in the
central part of HDH. This region does not correspond to the part of the enzyme
that, in most, but not all HDH sequences contains a cysteine residue which, in
Salmonella typhimurium, has  been  said  [2] to be important for the catalytic
activity of the enzyme.

-Consensus pattern: [IVTPM]-[DEG]-x(2,3)-[AYEPQ]-G-[PT]-[ST]-[ED]-[LIVSTA]-
                    [LIVMAECGFT]-[LIVMA]-[LIVMAYF]-[ACNDSTI]-x(2,3)-[ACNGVST]-
                    x(4,6)-[LIVMAC]-[AVLKIT]-[SACLYWNRMTV]-[DEG]-[LIVMFCA]-
                    [LIVMKFR]-[SAGVI]-x(2)-E-H
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: April 2006 / Pattern revised.

[ 1] Nagai A., Ward E., Beck J., Tada S., Chang J.-Y., Scheidegger A.,
     Ryals J.
     "Structural and functional conservation of histidinol dehydrogenase
     between plants and microbes."
     Proc. Natl. Acad. Sci. U.S.A. 88:4133-4137(1991).
     PubMed=2034659
[ 2] Grubmeyer C.T., Gray W.R.
     "A cysteine residue (cysteine-116) in the histidinol binding site of
     histidinol dehydrogenase."
     Biochemistry 25:4778-4784(1986).
     PubMed=3533140

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