{PDOC00539}
{PS00617; RECF_1}
{PS00618; RECF_2}
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* recF protein signatures *
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The prokaryotic protein recF [1,2]  is a  single-stranded DNA-binding  protein
which also probably binds  ATP.  RecF  is  involved in DNA  metabolism;  it is
required for recombinational DNA repair and for induction of the SOS response.

RecF is a protein of  about  350  to  370  amino  acid  residues;  there  is a
conserved ATP-binding site motif 'A' (P-loop) in the N-terminal section of the
protein as well as two  other  conserved regions,  one  located in the central
section, and the other in the C-terminal section.  We  have  derived signature
patterns from these two regions.

-Consensus pattern: [LIFV]-x(6)-[LIF]-[LIVF]-x-[GSDE]-[GSTADNPE]-[PASG]-x(2)-
                    R-R-x-[FYW]-[LIVMF]-[DN]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Consensus pattern: [LIV]-[LIFYMV]-x-[LIVM]-D-[DEA]-[LIVF]-x(2)-[EHCGK]-L-D-
                    x(2)-[KRH]-x(3)-[LIVF]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: April 2006 / Pattern revised.

[ 1] Sandler S.J., Chackerian B., Li J.T., Clark A.J.
     "Sequence and complementation analysis of recF genes from Escherichia
     coli, Salmonella typhimurium, Pseudomonas putida and Bacillus
     subtilis: evidence for an essential phosphate binding loop."
     Nucleic Acids Res. 20:839-845(1992).
     PubMed=1542576
[ 2] Alonso J.C., Fisher L.M.
     "Nucleotide sequence of the recF gene cluster from Staphylococcus
     aureus and complementation analysis in Bacillus subtilis recF
     mutants."
     Mol. Gen. Genet. 246:680-686(1995).
     PubMed=7898435

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