{PDOC00541}
{PS00621; TISSUE_FACTOR}
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* Tissue factor signature *
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Tissue factor (TF) [1,2] is an integral membrane glycoprotein  that  initiates
blood coagulation by forming a  complex  with  circulating factor VII or VIIa.
The complex then activates factors IX or X by specific limited proteolysis.

The mature  form of TF  is  a protein of about  250  amino acid  residues.  TF
consists of an  extracellular domain of about 210 residues  that  contains two
disulfide bonds, followed  by  a transmembrane  region and a short cytoplasmic
C-terminal  domain.  This  structure  is  shown  in  the  following  schematic
representation:

   +----------*****---------------------------------------xxxxx----+
   |           C C       Extracellular            C    C  XXXXX Cyt|
   +-----------|-|--------------------------------|----|--xxxxx----+
               | |                                |    |  Transm.
               +-+                                +----+

'C': conserved cysteine involved in a disulfide bond.
'*': position of the pattern.

As a pattern for TF,  we  have used the region centered on  the  two cysteines
involved in the first disulfide bond.

-Consensus pattern: W-K-x-K-C-x(2)-T-x-[DEN]-T-E-C-D-[LIVM]-T-D-E
                    [The 2 C's are linked by a disulfide bond]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: May 2004 / Text revised.

[ 1] Bach R.R.
     "Initiation of coagulation by tissue factor."
     CRC Crit. Rev. Biochem. 23:339-368(1988).
     PubMed=3067973
[ 2] Barcham G.J., Andrews A.E., Nash A.D.
     "Cloning and expression of a cDNA encoding ovine interleukin 7."
     Gene 154:265-269(1995).
     PubMed=7890175

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