{PDOC00545}
{PS00627; GHMP_KINASES_ATP}
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* GHMP kinases putative ATP-binding domain *
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The following kinases contains, in  their N-terminal section, a conserved Gly/
Ser-rich region which is probably involved in  the binding of ATP [1].   These
kinases are listed below.

 - Galactokinase (EC 2.7.1.6).
 - Homoserine kinase (EC 2.7.1.39).
 - Mevalonate kinase (EC 2.7.1.36).
 - Phosphomevalonate kinase (EC 2.7.4.2).

We have called this group of kinases 'GHMP' (from  the  first  letter of their
substrate).

-Consensus pattern: [LIVM]-[PK]-x-[GSTA]-x(0,1)-G-[LM]-[GS]-S-S-[GSA]-[GSTAC]
-Sequences known to belong to this class detected by the pattern: ALL,  except
 for P.aeruginosa homoserine kinase which does not  seem to be homologous with
 the other GHMP kinases.
-Other sequence(s) detected in Swiss-Prot: 1.
-Last update: December 2001 / Pattern and text revised.

[ 1] Tsay Y.H., Robinson G.W.
     "Cloning and characterization of ERG8, an essential gene of
     Saccharomyces cerevisiae that encodes phosphomevalonate kinase."
     Mol. Cell. Biol. 11:620-631(1991).
     PubMed=1846667

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