{PDOC00584}
{PS00702; GM_CSF}
{BEGIN}
**************************************************************
* Granulocyte-macrophage colony-stimulating factor signature *
**************************************************************

Granulocyte-macrophage colony-stimulating factor  (GM-CSF) [1,2] is a cytokine
that acts in hematopoiesis by  stimulating  the growth  and differentiation of
hematopoietic  precursor cells from various lineages,  including granulocytes,
macrophages, eosinophils and erythrocytes.

GM-CSF is a glycoprotein of  about  120 amino acid residues that contains four
conserved cysteine  residues involved in  two disulfide bonds, as shown in the
following schematic representation.

                                                   +---------------+
                                                   |               |
        xxxxxxxxxxxxxxxxxxxxxxxxxxCxxxxxxxxxxxxxxxxCxxxCxxxxxxxxxxxCxxx
                                  |                *****
                                  +--------------------+

'C': conserved cysteine involved in a disulfide bond.
'*': position of the pattern.

As a signature pattern, we selected the region  that  includes  the second and
third conserved cysteines.

-Consensus pattern: C-P-[LP]-T-x-E-[ST]-x-C
                    [The 2 C's are involved in disulfide bonds]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: May 2004 / Text revised.

[ 1] Morstyn G., Burgess A.W.
     "Hemopoietic growth factors: a review."
     Cancer Res. 48:5624-5637(1988).
     PubMed=2458827
[ 2] Walter M.R., Cook W.J., Ealick S.E., Nagabhushan T.L., Trotta P.P.,
     Bugg C.E.
     "Three-dimensional structure of recombinant human
     granulocyte-macrophage colony-stimulating factor."
     J. Mol. Biol. 224:1075-1085(1992).
     PubMed=1569568

--------------------------------------------------------------------------------
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html
--------------------------------------------------------------------------------

{END}