{PDOC00609}
{PS00748; F_ACTIN_CAPPING_A_1}
{PS00749; F_ACTIN_CAPPING_A_2}
{BEGIN}
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* F-actin capping protein alpha subunit signatures *
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The F-actin capping protein binds in  a calcium-independent manner to the fast
growing ends of  actin filaments (barbed end) thereby blocking the exchange of
subunits at these ends.   Unlike  gelsolin  and  severin this protein does not
sever actin filaments.  The  F-actin capping protein is a heterodimer composed
of two unrelated subunits: alpha and beta.

The alpha subunit is a protein of about 268 to 308  amino  acid residues whose
sequence is well conserved in eukaryotic species [1].   As  signature patterns
we  selected  two highly  conserved regions in the C-terminal section  of  the
alpha subunit.

-Consensus pattern: [VA]-H-[FY](2)-[ER]-[DEC]-[GV]-N-[VL]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Consensus pattern: K-x-[LM]-R-R-x-L-P-[IV]-[NT]-R
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: December 2004 / Pattern and text revised.

[ 1] Cooper J.A., Caldwell J.E., Gattermeir D.J., Torres M.A., Amatruda J.F.,
     Casella J.F.
     "Variant cDNAs encoding proteins similar to the alpha subunit o
     chicken CapZ."
     Cell Motil. Cytoskeleton 18:204-214(1991).
     PubMed=1711931;

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