{PDOC00632}
{PS00795; INVOLUCRIN}
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* Involucrin signature *
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Involucrin [1,2] is a protein present in keratinocytes of epidermis and other
stratified squamous epithelia.  Involucrin  first appears in the cell cytosol,
but ultimately  becomes cross-linked  to membrane proteins by transglutaminase
thus helping in  the  formation  of  an  insoluble envelope beneath the plasma
membrane.

Structurally  involucrin consists of a conserved region of about 75 amino acid
residues  followed  by  two  extremely  variable length segments  that contain
glutamine-rich tandem repeats. The  glutamine  residues  in the tandem repeats
are the substrate for the tranglutaminase in the cross-linking reaction.   The
total size of the protein  varies  from  285 residues (in dog) to 835 residues
(in orangutan).

The signature pattern for  involucrin  corresponds to the N-terminal extremity
of the protein.

-Consensus pattern: <M-S-[QH]-Q-x-T-[LV]-P-V-T-[LV]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: November 1997 / Pattern and text revised.

[ 1] Green H., Djian P.
     "Consecutive actions of different gene-altering mechanisms in the
     evolution of involucrin."
     Mol. Biol. Evol. 9:977-1017(1992).
     PubMed=1359382
[ 2] Djian P., Phillips M., Easley K., Huang E., Simon M., Rice R.H., Green H.
     "The involucrin genes of the mouse and the rat: study of their shared
     repeats."
     Mol. Biol. Evol. 10:1136-1149(1993).
     PubMed=8277848

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