{PDOC00634}
{PS00799; GRANULINS}
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***********************
* Granulins signature *
***********************

Granulins [1] are a family of cysteine-rich  peptides  of about 6 Kd which may
have multiple  biological  activity. A precursor protein (known as acrogranin)
potentially encodes seven different forms of granulin (grnA to grnG) which are
probably released by post-translational proteolytic processing.    A schematic
representation of the structure of a granulin is shown below:

       xxxCxxxxxCxxxxxCCxxxxxxxxCCxxxxxxCCxxxxxCCxxxxxCxxxxxxCx
                                         **************

'C': conserved cysteine probably involved in a disulfide bond.
'*': position of the pattern.

Granulins are evolutionary related to a PMP-D1, a  peptide  extracted from the
pars intercerebralis of migratory locusts [2].

-Consensus pattern: C-x-D-x(2)-H-C-C-P-x(4)-C
                    [The 4 C's may be involved in disulfide bonds]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: May 2004 / Text revised.

[ 1] Bhandari V., Palfree R.G., Bateman A.
     "Isolation and sequence of the granulin precursor cDNA from human bone
     marrow reveals tandem cysteine-rich granulin domains."
     Proc. Natl. Acad. Sci. U.S.A. 89:1715-1719(1992).
     PubMed=1542665
[ 2] Nakakura N., Hietter H., Van Dorsselaer A., Luu B.
     "Isolation and structural determination of three peptides from the
     insect Locusta migratoria. Identification of a deoxyhexose-linked
     peptide."
     Eur. J. Biochem. 204:147-153(1992).
     PubMed=1740125

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