{PDOC00660}
{PS00845; CAP_GLY_1}
{PS50245; CAP_GLY_2}
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* CAP-Gly domain signature and profile *
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It has been shown [1]  that  some cytoskeleton-associated proteins (CAP) share
the presence  of a conserved, glycine-rich domain of about 42 residues, called
here CAP-Gly. Proteins known to contain this domain are listed below.

 - Restin (also known as cytoplasmic linker protein-170 or CLIP-170), a 160 Kd
   protein associated  with  intermediate  filaments  and that links endocytic
   vesicles to microtubules. Restin contains two copies of the CAP-Gly domain.
 - Vertebrate   dynactin  (150  Kd  dynein-associated  polypeptide;  DAP)  and
   Drosophila glued,  a  major  component  of  activator  I, a 20S polypeptide
   complex that stimulates dynein-mediated vesicle transport.
 - Yeast protein  BIK1  which seems  to  be  required  for  the  formation  or
   stabilization of  microtubules  during  mitosis  and  for spindle pole body
   fusion during conjugation.
 - Yeast protein NIP100 (NIP80).
 - Human  protein  CKAP1/TFCB,  Schizosaccharomyces  pombe  protein  alp11 and
   Caenorhabditis elegans hypothetical protein F53F4.3. These proteins contain
   a N-terminal ubiquitin domain (see <PDOC00271>) and a C-terminal CAP-Gly
   domain.
 - Caenorhabditis elegans hypothetical protein M01A8.2.
 - Yeast hypothetical protein YNL148c.

Structurally, these  proteins  are made of three distinct parts: an N-terminal
section that  is  most  probably  globular  and contains the CAP-Gly domain, a
large central   region   predicted  to  be  in  an  alpha-helical  coiled-coil
conformation and, finally, a short C-terminal globular domain.

The signature for the CAP-Gly domain  corresponds  to the first 32 residues of
the domain and includes five of the six conserved glycines. A profile was also
developed that spans the complete CAP-Gly domain.

-Consensus pattern: [GD]-x(0,10)-[FYWA]-x(0,1)-G-[LIVM]-x(0,2)-[LIVMFYD]-
                    x(0,7)-G-[KN]-[NHW]-x(0,1)-G-[STARCV]-x(0,2)-[GD]-x(0,2)-
                    [LY]-[FC]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Sequences known to belong to this class detected by the profile: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: April 2006 / Pattern revised.

[ 1] Riehemann K., Sorg C.
     "Sequence homologies between four cytoskeleton-associated proteins."
     Trends Biochem. Sci. 18:82-83(1993).
     PubMed=8480366

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