{PDOC00667}
{PS00853; BETA_ELIM_LYASE}
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* Beta-eliminating lyases pyridoxal-phosphate attachment site *
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Tryptophan indole-lyase  (EC  4.1.99.1)  (tryptophanase)  and tyrosine phenol-
lyase (EC   4.1.99.2)   (beta-tyrosinase)   are   related  pyridoxal-phosphate
dependent homotetrameric  enzymes  [1].  Tryptophan indole-lyase catalyzes the
transformation of  tryptophan  into  indole, pyruvate and ammonia and tyrosine
phenol-lyase transforms tyrosine into phenol, pyruvate and ammonia.

Both enzymes are proteins that contains 450 to 470 amino acids. The pyridoxal-
phosphate group  is attached to a lysine residue in the central section of the
sequence.

-Consensus pattern: [YV]-x-D-x(3)-M-S-[GA]-K-K-D-x-[LIVMF]-[LIVMAG]-x-[LIVM]-
                    G-G
                    [The second K is the pyridoxal-P attachment site]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2004 / Pattern and text revised.

[ 1] Iwamori S., Yoshino S., Ishiwata K., Makiguchi N.
     J. Ferment. Bioeng. 72:147-151(1991).

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