{PDOC00669}
{PS00855; SPASE_II}
{BEGIN}
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* Signal peptidases II signature *
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Signal peptidases (SPases) [1]  (also  known  as leader peptidases) remove the
signal peptides from secretory proteins.  In prokaryotes three types of SPases
are known: type I (gene lepB) which is responsible for  the  processing of the
majority  of  exported pre-proteins;  type II (gene lsp)  which  only  process
lipoproteins, and a third type involved in the processing of pili subunits.

SPase II   (EC 3.4.23.36),   also   known  as  lipoprotein  signal  peptidase,
recognizes a  conserved  sequence  and  cuts in front of a cysteine residue to
which a  glyceride-fatty  acid  lipid  is  attached.  SPase  II is an integral
membrane protein that is anchored in the cytoplasmic membrane.

There are  a  number  of  conserved  regions  in the sequence of Spase II from
various bacteria  [2],  we  have  selected one of these regions as a signature
pattern.

-Consensus pattern: [LIVM]-x-[GASF]-[GA]-[GAST]-[LIVMTF]-[GAS]-N-[LVMFGIA]-
                    [LIVFYGT]-D-[RIK]-[LIVMFAC]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Note: These proteins belong to family A8 in  the classification of peptidases
 [3,E1].

-Expert(s) to contact by email:
           von Heijne G.; gunnar@biokemi.su.se

-Last update: April 2006 / Pattern revised.

[ 1] Dalbey R.E., Von Heijne G.
     "Signal peptidases in prokaryotes and eukaryotes--a new protease
     family."
     Trends Biochem. Sci. 17:474-478(1992).
     PubMed=1455520
[ 2] Zhao X.J., Wu H.C.
     "Nucleotide sequence of the Staphylococcus aureus signal peptidase II
     (lsp) gene."
     FEBS Lett. 299:80-84(1992).
     PubMed=1544479
[ 3] Rawlings N.D., Barrett A.J.
     "Evolutionary families of metallopeptidases."
     Methods Enzymol. 248:183-228(1995).
     PubMed=7674922
[E1] https://www.uniprot.org/docs/peptidas

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