{PDOC00675}
{PS00863; CALSEQUESTRIN_1}
{PS00864; CALSEQUESTRIN_2}
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* Calsequestrin signatures *
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Calsequestrin is   a  moderate-affinity, high-capacity calcium-binding protein
of cardiac  and  skeletal muscle [1], where it is located in the lumenal space
of the  sarcoplasmic  reticulum  terminal  cisternae.  Calsequestrin acts as a
calcium  buffer  and  plays  an important   role  in  the  muscle  excitation-
contraction coupling.  It  is  a highly acidic protein of about 400 amino acid
residues that  binds  more than 40 moles of calcium per mole of protein. There
are at  least two different forms of calsequestrin: one which is expressed  in
cardiac muscles  and  another  in  skeletal  muscles.  Both  forms have highly
similar sequences.

We have developed two signature sequences, the first one corresponds to the N-
terminus of  the  mature  protein;  the second is located just in front of the
C-terminus  of  the  protein  which is  composed  of  a  highly acidic tail of
variable length.

-Consensus pattern: [EQ]-[DE]-G-L-[DN]-F-P-x-Y-D-G-x-D-R-V
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Consensus pattern: [DE]-L-E-D-W-[LIVM]-E-D-V-L-x-G-x-[LIVM]-N-T-E-D-D-D
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Last update: October 1993 / First entry.

[ 1] Treves S., Vilsen B., Chiozzi P., Andersen J.P., Zorzato F.
     "Molecular cloning, functional expression and tissue distribution of
     the cDNA encoding frog skeletal muscle calsequestrin."
     Biochem. J. 283:767-772(1992).
     PubMed=1375450

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