{PDOC00682}
{PS00874; T2SP_F}
{BEGIN}
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* Bacterial type II secretion system protein F signature *
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A number  of  bacterial  proteins,  some  of  which  are involved in a general
secretion pathway  (GSP) for the export  of  proteins (also called the type II
pathway) [1], have  been  found to be evolutionary related. These proteins are
listed below.

 - The    'F'   protein from the GSP operon of: Aeromonas (gene exeF); Erwinia
   (gene outF);  Escherichia  coli  (gene  hofF);  Klebsiella pneumoniae (gene
   pulF); Pseudomonas aeruginosa (gene xcpS);  Vibrio cholerae (gene epsF) and
   Xanthomonas campestris (gene xpsF).
 - Bacillus subtilis comG operon protein 2 which is required for the uptake of
   DNA by competent Bacillus subtilis cells.
 - Aeromonas hydrophila tapC, involved in type IV pilus assembly.
 - Pseudomonas protein pilC, which is essential for the formation of the pili.
 - Vibrio cholerae protein tcpE, which  is involved in the biosynthesis of the
   tcp pilus.
 - Escherichia coli protein hofC (hopC).

These are  proteins  of  about 400 amino acids that are highly hydrophobic and
which are thought to be integral protein of the inner membrane. As a signature
pattern we selected a conserved region in the central part of these proteins.

-Consensus pattern: [KRQ]-[LIVMAW]-x(2)-[SAIV]-[LIVM]-x-[TY]-P-x(2)-[LIVM]-
                    x(3)-[STAGV]-x(6)-[LMY]-x(3)-[LIVMF](2)-P
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: December 2004 / Pattern and text revised.

[ 1] Salmond G.P.C., Reeves P.J.
     "Membrane traffic wardens and protein secretion in gram-negative
     bacteria."
     Trends Biochem. Sci. 18:7-12(1993).
     PubMed=8438237
[ 2] Hobbs M., Mattick J.S.
     "Common components in the assembly of type 4 fimbriae, DNA transfer
     systems, filamentous phage and protein-secretion apparatus: a general
     system for the formation of surface-associated protein complexes."
     Mol. Microbiol. 10:233-243(1993).
     PubMed=7934814

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