{PDOC00708}
{PS00911; DHODEHASE_1}
{PS00912; DHODEHASE_2}
{BEGIN}
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* Dihydroorotate dehydrogenase signatures *
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Dihydroorotate dehydrogenase  (EC 1.3.3.1)  (DHOdehase)  catalyzes  the fourth
step in   the   de   novo   biosynthesis  of  pyrimidine,  the  conversion  of
dihydroorotate into orotate. DHOdehase is a ubiquitous FAD flavoprotein.

In bacteria  (gene pyrD), DHOdease  is  located    on  the  inner  side of the
cytosolic membrane.  In some yeasts, such as in Saccharomyces cerevisiae (gene
URA1), it is a cytosolic  protein while in other eukaryotes it is found in the
mitochondria [1].

The sequence  of  DHOdease  is rather well conserved and we have developed two
signature patterns  specific to this enzyme. The first corresponds to a region
in the N-terminal section of the enzyme while the second is located in  the C-
terminal section and seems to be part of the FAD-binding domain.

-Consensus pattern: [GSA]-x(4)-[GK]-[GSTA]-[LIVFSTA]-[GST]-x(3)-[NQRK]-x-G-
                    [NHY]-x(2)-P-[RTV]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Consensus pattern: [LIVM](2)-[GSA]-x-G(2)-[IV]-x-[STGDN]-x(3)-[ACV]-x(2)-{A}-
                    {R}-x-{L}-G-A
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: 10.

-Last update: April 2006 / Pattern revised.

[ 1] Nagy M., Lacroute F., Thomas D.
     "Divergent evolution of pyrimidine biosynthesis between anaerobic and
     aerobic yeasts."
     Proc. Natl. Acad. Sci. U.S.A. 89:8966-8970(1992).
     PubMed=1409592

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