{PDOC00709} {PS00914; SYNTAXIN} {BEGIN} ****************************************** * Syntaxin / epimorphin family signature * ****************************************** The following proteins have been shown to be evolutionary related [1,2,3]: - Epimorphin (or syntaxin 2), a mammalian mesenchymal protein which plays an essential role in epithelial morphogenesis. - Syntaxin 1A (also known as antigen HPC-1) and syntaxin 1B which are synaptic proteins which may be involved in docking of synaptic vesicles at presynaptic active zones. - Syntaxin 3. - Syntaxin 4, which is potentially involved in docking of synaptic vesicles at presynaptic active zones. - Syntaxin 5, which mediates endoplasmic reticulum to golgi transport. - Syntaxin 6, which is involved in intracellular vesicle trafficking. - Syntaxin 7. - Yeast PEP12 (or VPS6) which is required for the transport of proteases to the vacuole. - Yeast SED5 which is required for the fusion of transport vesicles with the Golgi complex. - Yeast SSO1 and SSO2 which are required for vesicle fusion with the plasma membrane. - Yeast VAM3, which is required for vacuolar assembly. - Arabidopsis thaliana protein KNOLLE which may be involved in cytokinesis. - Caenorhabditis elegans hypothetical proteins F35C8.4, F48F7.2, F55A11.2 and T01B11.3. The above proteins share the following characteristics: a size ranging from 30 Kd to 40 Kd; a C-terminal extremity which is highly hydrophobic and is probably involved in anchoring the protein to the membrane; a central, well conserved region, which seems to be in a coiled-coil conformation. The pattern specific for this family is based on the most conserved region of the coiled coil domain. -Consensus pattern: [RQLKA]-x(3)-[LIVMAW]-x(2)-[LIVM]-[ESHLKAGQV]-x(2)- [LIVMT]-x-[DEVMNRAST]-[LIVMT]-x(2)-[LIVMQ]-[FSAQGVM]-x(2)- [LIVMF]-x(3)-[LIVT]-x(2)-Q-[GADEQVST]-x(2)-[LIVMA]- [DNQTEI]-x-[LIVMF]-[DESVHAG]-x(2,3)-[LIVM] -Sequences known to belong to this class detected by the pattern: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: December 2004 / Pattern and text revised. [ 1] Bennett M.K., Garcia-Arraras J.E., Elferink L.A., Peterson K., Fleming A.M., Hazuka C.D., Scheller R.H. "The syntaxin family of vesicular transport receptors." Cell 74:863-873(1993). PubMed=7690687 [ 2] Spring J., Kato M., Bernfield M. "Epimorphin is related to a new class of neuronal and yeast vesicle targeting proteins." Trends Biochem. Sci. 18:124-125(1993). PubMed=8493722 [ 3] Pelham H.R.B. "Is epimorphin involved in vesicular transport?" Cell 73:425-426(1993). PubMed=8490959 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}