{PDOC00726} {PS00942; GLPT} {BEGIN} ***************************************** * glpT family of transporters signature * ***************************************** The following proteins involved in the uptake of phosphorylated metabolites, are evolutionary related [1,2]: - Escherichia coli, Bacillus subtilis and Haemophilus influenzae glycerol-3- phosphate transporter (gene glpT). - Salmonella typhimurium phosphoglycerate transporter (gene pgtP). - Escherichia coli and Salmonella typhimurium hexose-6-phosphate transporter (gene uhpT). - Escherichia coli and Salmonella typhimurium protein uhpC. UhpC is necessary for the expression of uhpT and seems to act jointly with the uhpB sensor/ kinase protein. - Human glucose 6-phosphate translocase [3]. These proteins of about 50 Kd apparently contain 12 transmembrane regions. As a signature pattern we selected a conserved region in their central section. -Consensus pattern: [QEK]-[RF]-G-x(3)-[GSA]-[LIVF]-[WL]-[NS]-x-[SA]-[HM]-N- [LIV]-[GA]-G -Sequences known to belong to this class detected by the pattern: ALL. -Other sequence(s) detected in Swiss-Prot: NONE. -Last update: July 1999 / Pattern and text revised. [ 1] Goldrick D., Yu G.-Q., Jiang S.-Q., Hong J.S. "Nucleotide sequence and transcription start point of the phosphoglycerate transporter gene of Salmonella typhimurium." J. Bacteriol. 170:3421-3426(1988). PubMed=3042749 [ 2] Marger M.D., Saier M.H. Jr. "A major superfamily of transmembrane facilitators that catalyse uniport, symport and antiport." Trends Biochem. Sci. 18:13-20(1993). PubMed=8438231 [ 3] Gerin I., Veiga-da-Cunha M., Achouri Y., Collet J.-F., Van Schaftingen E. "Sequence of a putative glucose 6-phosphate translocase, mutated in glycogen storage disease type Ib." FEBS Lett. 419:235-238(1997). PubMed=9428641 -------------------------------------------------------------------------------- PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives (CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html -------------------------------------------------------------------------------- {END}