{PDOC00742}
{PS00960; BTG_1}
{PS01203; BTG_2}
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* BTG family signatures *
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A novel   family  of  anti-proliferative  proteins  has  been  recently  [1,2]
characterized:

 - Mammalian  and  avian  protein BTG1. BTG1 seems to negatively regulate cell
   proliferation.
 - Mammalian protein BTG2 (also known as PC3 or TIS21).
 - Mammalian protein BTG3 (also known as TOB5).
 - Mammalian protein BTG4 (also known as PC3b).
 - Mammalian  protein  TOB,  an anti-proliferative protein that interacts with
   the erbb-2 receptor tyrosine kinase [3].
 - Human protein TOB4.
 - Xenopus  laevis  maternal  proteins B9.10 and B9.15 (which are probably the
   orthologs of BTG3).

The proteins  have  from  158 to 363 amino acid residues. BTG2 seems to have a
signal sequence; while the other proteins may lack such a domain. The sequence
of the  N-terminal  half  of  these  proteins  is well conserved. As signature
patterns, we  selected  the  two best conserved regions of these proteins. The
first signature pattern includes the only conserved cysteine.

-Consensus pattern: Y-x(2)-[HP]-W-[FYH]-[APS]-[DE]-x-P-x-K-G-x-[GA]-[FY]-R-C-
                    [IV]-[RH]-[IV]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Consensus pattern: [LV]-P-x-[DE]-[LM]-[ST]-[LIVM]-W-[IV]-D-P-x-E-V-[SC]-x-
                    [RQ]-x-G-[EK]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Expert(s) to contact by email:
           Duret L.; duret@biomserv.univ-lyon1.fr

-Last update: April 2006 / Pattern revised.

[ 1] Rouault J.-P., Rimokh R., Tessa C., Paranhos G., Ffrench M., Duret L.,
     Garoccio M., Germain D., Samarut J., Magaud J.-P.
     "BTG1, a member of a new family of antiproliferative genes."
     EMBO J. 11:1663-1670(1992).
     PubMed=1373383
[ 2] Rouault J.-P., Samarut C., Duret L., Tessa C., Samarut J., Magaud J.-P.
     "Sequence analysis reveals that the BTG1 anti-proliferative gene is
     conserved throughout evolution in its coding and 3' non-coding
     regions."
     Gene 129:303-306(1993).
     PubMed=8325512
[ 3] Matsuda S., Kawamura-Tsuzuku J., Ohsugi M., Yoshida M., Emi M.,
     Nakamura Y., Onda M., Yoshida Y., Nishiyama A., Yamamoto T.
     "Tob, a novel protein that interacts with p185erbB2, is associated
     with anti-proliferative activity."
     Oncogene 12:705-713(1996).
     PubMed=8632892

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