{PDOC00752}
{PS00975; NMT_1}
{PS00976; NMT_2}
{BEGIN}
***********************************************************
* Myristoyl-CoA:protein N-myristoyltransferase signatures *
***********************************************************

Myristoyl-CoA:protein N-myristoyltransferase  (EC 2.3.1.97)  (Nmt) [1]  is the
enzyme responsible  for  transferring  a  myristate  group  on  the N-terminal
glycine of a number of cellular eukaryotics and viral proteins.

Nmt is  a  monomeric protein of about 50 to 60 Kd whose sequence appears to be
well conserved.  We  used  two highly conserved regions as signature patterns.
The first  one is located in the central section, the second in the C-terminal
part.

-Consensus pattern: [DEK]-[IV]-N-[FS]-L-C-x-H-K
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.

-Consensus pattern: K-F-G-x-G-D-G
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: 1.

-Last update: April 2006 / Pattern revised.

[ 1] Rudnick D.A., McWherter C.A., Gokel G.W., Gordon J.I.
     "MyristoylCoA:protein N-myristoyltransferase."
     Adv. Enzymol. Relat. Areas Mol. Biol. 67:375-430(1993).
     PubMed=8322618

--------------------------------------------------------------------------------
PROSITE is copyrighted by the SIB Swiss Institute of Bioinformatics and
distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives
(CC BY-NC-ND 4.0) License, see https://prosite.expasy.org/prosite_license.html
--------------------------------------------------------------------------------

{END}