{PDOC00755}
{PS00982; PHYTOENE_DH}
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* Bacterial-type phytoene dehydrogenase signature *
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Phytoene dehydrogenase  (phytoene  desaturase)  is  an  enzyme  of  carotenoid
biosynthesis that  converts  phytoene  into  zeta-carotene via the symmetrical
introduction of  two double bonds at the C-11 and C-11' positions of phytoene.
The sequence  of  phytoene dehydrogenase from bacteria (gene crtI or carC) and
fungi (gene AL-1) are not related to that from cyanobacteria and plants but is
evolutionary related [1] to that of another enzyme of carotenoid biosynthesis,
methoxyneurosporene dehydrogenase (gene crtD).

There are  two  glycine-rich  conserved regions, both of which probably play a
role in the binding of either FAD or NAD. The first conserved region is in the
N-terminal section  while the second one is in the C-terminal section. We have
used the second region as a signature pattern.

-Consensus pattern: [NG]-x-[FYWV]-[LIVMF]-x-G-[AGC]-[GS]-[TA]-[HQT]-P-G-
                    [STAV]-G-[LIVM]-x(5)-[GS]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: November 1997 / Pattern and text revised.

[ 1] Bartley G.E., Schmidhauser T.J., Yanofsky C., Scolnik P.A.
     "Carotenoid desaturases from Rhodobacter capsulatus and Neurospora
     crassa are structurally and functionally conserved and contain domains
     homologous to flavoprotein disulfide oxidoreductases."
     J. Biol. Chem. 265:16020-16024(1990).
     PubMed=2144293

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