{PDOC00757}
{PS00984; UROTENSIN_II}
{BEGIN}
**************************
* Urotensin II signature *
**************************

Urotensin II  [1,2]  is  a  small  peptide originally isolated from the caudal
portion of the spinal cord of teleost and elasmobranch fish but which has also
been found in the brain of frogs.  Urotensin II seems to be involved in smooth
muscle stimulation.  It  is  a  peptide  of  12 to 13 residues that contains a
disulfide bridge.

                               +---+
                               |   |
                         xxxxxxCxxxCx
                               ******

'C': conserved cysteine involved in a disulfide bond.
'*': position of the pattern.

-Consensus pattern: C-F-W-K-Y-C
                    [The 2 C's are linked by a disulfide bond]
-Sequences known to belong to this class detected by the pattern: ALL.
-Other sequence(s) detected in Swiss-Prot: NONE.
-Last update: May 2004 / Text revised.

[ 1] Conlon J.M., O'Harte F., Smith D.D., Tonon M.-C., Vaudry H.
     "Isolation and primary structure of urotensin II from the brain of a
     tetrapod, the frog Rana ridibunda."
     Biochem. Biophys. Res. Commun. 188:578-583(1992).
     PubMed=1445302
[ 2] Conlon J.M., O'Harte F., Smith D.D., Balment R.J., Hazon N.
     "Purification and characterization of urotensin II and parvalbumin
     from an elasmobranch fish, Scyliorhinus canicula (common dogfish)."
     Neuroendocrinology 55:230-235(1992).
     PubMed=1620290

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